Scientific Publications
Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFB receptor degradation in breast cancer
Fucoidan inhibition of lung cancer in vivo and in vitro: role of the Smurf2-dependent ubiquitin proteasome pathway in TGFB receptor degradation
Inhibitory effects of high stability fucoxanthin on palmitic acid-induced lipid accumulation in human adipose-derived stem cells through modulation of long non-coding RNA
Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells
Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1VEGF Signaling under Hypoxia
Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells
Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo
The Oligo Fucoidan Inhibits Platelet-Derived Growth Factor-Stimulated Proliferation of Airway Smooth Muscle Cells
Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice
A mechanism of low molecular weight fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29cADAM12 and miR-17-5pPTEN Axes in Human Breast Cancer Cells
Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway
Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes
Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial
Fucoidan ameliorates pancreatic β-cell death and impaired insulin synthesis in streptozotocin-treated β cells and mice via a Sirt-1-dependent manner
Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer
Fucoidan and Fucoxanthin Ameliorate Cardiac Function of Aging Canine
Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression
Fucoidan upregulates TLR4CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells
Alleviative effect of fucoxanthin-containing extract from brown seaweed Laminaria japonica on renal tubular cell apoptosis through upregulating Na+/H+ exchanger NHE1 in chronic kidney disease mice
Fucoidan inhibits the proliferation of leiomyoma 1 cells and decreases extracellular matrix-associated protein expression
Oligo‑fucoidan improved unbalance the Th1Th2 and TregTh17 ratios in asthmatic patients An ex vivo study
Fucoidan Inhibits Radiation-Induced and Lung Fibrosis by Reducing Inflammatory Pneumonitis Cytokine Expression in Lung Tissues
The anti-tumor activity of brown seaweed oligo-fucoidan via lncRNA expression modulation in HepG2 cells
Fucoidan–Fucoxanthin Ameliorated Cardiac Function via IRS1 GRB2 SOS1 GSK3 CREB Pathways and Metabolic Pathways in Senescent Mice
Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy
Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity
Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate
Low-molecular-weight fucoidan and high-stability fucoxanthin decrease serum alanine transaminase in patients with nonalcoholic fatty liver disease--A double-blind, randomized controlled trial
The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase
Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression
Radioprotective effect of self-assembled low molecular weight Fucoidan–Chitosan nanoparticles
Protective Effect of Low-Molecular-Weight Fucoidan on Radiation-Induced Fibrosis Through TGF-β1/Smad Pathway-Mediated Inhibition of Collagen I Accumulation
Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPRSTAT3HNF4A Axis
Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model
Combined protective effects of oligo-fucoidan, fucoxanthin, and L-carnitine on the kidneys of chronic kidney disease mice
The Potential Effect of Fucoidan on Inhibiting Epithelial-to-Mesenchymal Transition, Proliferation, and Increase in Apoptosis for Endometriosis Treatment: In Vivo and In Vitro Study
Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells
Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling
Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study
Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis
Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression
Protective Effects of Fucoxanthin on Hydrogen Peroxide-Induced Calcification of Heart Valve Interstitial Cells
Enhanced Cellular Uptake in an Electrostatically Interacting Fucoidan-L-Arginine Fiber Complex
Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer
The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy A Double-Blinded Study
The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy: A Double-Blinded Study
Oligosaccharides Ameliorate Acute Kidney Injury by Alleviating Cluster of Differentiation 44-Mediated Immune Responses in Renal Tubular Cells
Sea Bass Essence from Lates calcarifer Improves Exercise Performance and Anti_Fatigue in Mice
Oligo‑Fucoidan supplementation enhances the effect of Olaparib on preventing metastasis and recurrence of triple‑negative breast cancer in mice
Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma: a randomized, double-blind, placebo-controlled trial
WNK1–OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy
Efficacy and Anti-Inflammatory Properties of Low-Molecular-Weight Fucoidan in Patients with Atopic Dermatitis a Randomized Double-Blinded Placebo-Controlled Trial
The Auxiliary Effects of Low-Molecular-Weight Fucoidan in Locally Advanced Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy Before A Double-Blind Randomized
Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload
Oral Administration of Oligo Fucoidan Improves the Survival Rate, Quality of Life, and Immunity in Patients with Lung Cancer-Food & Nutrition Research
Pressure induces peritoneal fibrosis and inflammation through CD44 signaling-Renal Failure
Therapeutic Potential of Oligo-Fucoidan in Mitigating Peritoneal Dialysis-Associated Fibrosis
To date, we have published over 60 scientific papers.
| Year | Publication Title | Journal | Full Article |
|---|---|---|---|
| 2024 | Therapeutic Potential of Oligo-Fucoidan in Mitigating Peritoneal Dialysis-Associated Fibrosis | Marine Drugs | |
| 2024 | Pressure Induces Peritoneal Fibrosis and Inflammation through CD44 Signaling | Renal Failure | |
| 2024 | Oral Administration of Oligo Fucoidan Improves the Survival Rate, Quality of Life, and Immunity in Patients with Lung Cancer | Food & Nutrition Research | |
| 2024 | Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload | Biomedicines | |
| 2023 | The Auxiliary Effects of Low-Molecular-Weight Fucoidan in Locally Advanced Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy Before A Double-Blind Randomized | Integrative Cancer Therapies | |
| 2023 | Efficacy and Anti-Inflammatory Properties of Low-Molecular-Weight Fucoidan in Patients with Atopic Dermatitis a Randomized Double-Blinded Placebo-Controlled Trial | International Journal of Food Properties | |
| 2023 | Therapeutic Efficacy, Radiotoxicity and Abscopal Effect of BNCT at the RA-3 Nuclear Reactor Employing Oligo-Fucoidan and Glutamine as Adjuvants in an Ectopic Colon Cancer Model in Rats | Life Journal from MDPI | |
| 2023 | Biochemical Characterization and Anti-Cancer Activity of Tangential Flow Filtration System Assisted Purification of Fucoglucan from Laminaria Japonica | International Journal of Biological Macromolecules | |
| 2022 | WNK1–OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy | International Journal of Molecular Sciences | |
| 2022 | Effects of Oligo-Fucoidan on the Immune Response, Inflammatory Status and Pulmonary Function in Patients with Asthma a Randomized Double-Blind Placebo-Controlled Trial | Scientific Reports | |
| 2022 | Oligo‑Fucoidan Supplementation Enhances the Effect of Olaparib on Preventing Metastasis and Recurrence of Triple‑Negative Breast Cancer in Mice | Journal of Biomedical Science | |
| 2022 | Sea Bass Essence from Lates calcarifer Improves Exercise Performance and Anti-Fatigue in Mice |
Metabolites | |
| 2022 | Oligosaccharides Ameliorate Acute Kidney Injury by Alleviating Cluster of Differentiation 44-Mediated Immune Responses in Renal Tubular Cells | Nutrients | |
| 2021 | The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy: A Double-Blinded Study | Topics in Companion Animal Medicine | |
| 2021 | Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum |
Marine Drugs | |
| 2021 | Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer | International Journal of Molecular Sciences | |
| 2021 | Enhanced Cellular Uptake in an Electrostatically Interacting Fucoidan-L-Arginine Fiber Complex | Polymers | |
| 2021 | Protective Effects of Fucoxanthin on Hydrogen Peroxide-Induced Calcification of Heart Valve Interstitial Cells | Marine Drugs | |
| 2021 | Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression | Frontiers in Oncology | |
| 2021 | Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis | Marine Drugs | |
| 2020 | Four Case Reports Effects of Fucoidan and Fucoxanthin on the Treatment of Degenerative Heart Valve Disease in Dogs | Journal of Animal Science and Veterinary Medicine | |
| 2020 | Fucoidan Increased the Sensitivity to Gefitinib in Lung Cancer Cells Correlates with Reduction of TGFβ-Mediated Slug Expression | International Journal of Biological Macromolecules | |
| 2020 | Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study | Nutrients | |
| 2020 | Low Molecular Weight Fucoidan Inhibits Hepatocarcinogenesis and Nonalcoholic Fatty Liver Disease in Zebrafish via ASGR/STAT3/HNF4A Signaling | Clinical and Translational Medicine | |
| 2020 | Protective Effects of Fucoxanthin on High Glucose and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells | Antioxidants | |
| 2020 | The Potential Effect of Fucoidan on Inhibiting Epithelial-to-Mesenchymal Transition, Proliferation, and Increase in Apoptosis for Endometriosis Treatment: In Vivo and In Vitro Study | Biomedicines | |
| 2020 | Combined Protective Effects of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on the Kidneys of Chronic Kidney Disease Mice | European Journal of Pharmacology | |
| 2020 | Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model | Cancers | |
| 2020 | Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis | Biomolecules | |
| 2020 | Protective Effect of Low‐Molecular‐Weight Fucoidan on Radiation‐Induced Fibrosis Through TGF‐β1/Smad Pathway‐Mediated Inhibition of Collagen I Accumulation | Marine Drugs | |
| 2020 | Radioprotective Effect of Self-Assembled Low Molecular Weight Fucoidan–Chitosan Nanoparticles. | Pharmaceutics | |
| 2020 | Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression. | Cancers | |
| 2020 | The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase. | Nutrients | |
| 2019 | Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan | Marine Drugs | |
| 2019 | Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin Decrease Serum Alanine Transaminase in Patients with Nonalcoholic Fatty Liver Disease—A Double-Blind, Randomized Controlled Trial | Advances in Digestive Medicine | |
| 2019 | Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate | Marine Drugs | |
| 2019 | Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity | Marine Drugs | |
| 2019 | Clinical Applications of Fucoidan in Translational Medicine for Adjuvant Cancer Therapy | Clinical and Translational Medicine | |
| 2019 | Fucoidan–Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice | Marine Drugs | |
| 2019 | The Anti-Tumor Activity of Brown Seaweed Oligo-Fucoidan via lncRNA Expression Modulation in HepG2 Cells | Cytotechnology | |
| 2018 | Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues | Marine Drugs | |
| 2018 | Oligo‑Fucoidan Improved Unbalance the Th1/Th2 and Treg/Th17 Ratios in Asthmatic Patients An ex vivo Study | Experimental and Therapeutic Medicine | |
| 2018 | Fucoidan inhibits the proliferation of leiomyoma cells and decreases extracellular matrix-associated protein expression | Cellular Physiology and Biochemistry | |
| 2018 | Alleviative Effect of Fucoxanthin-Containing Extract from Brown Seaweed Laminaria Japonica on Renal Tubular Cell Apoptosis through Upregulating Na+/H+ Exchanger NHE1 in Chronic Kidney Disease Mice | Journal of Ethnopharmacology | |
| 2018 | Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells | Cancer Letters | |
| 2017 | A Preliminary Study on the Application of Anti-Aging Cream with Small Molecular Fucoidan to Skin | Hung Kuang Journal | |
| 2017 | Oligo-Fucoidan Prevents IL-6 and CCL2 Production and Cooperates with p53 to Suppress ATM Signaling and Tumor Progression | Scientific Reports | |
| 2017 | Fucoidan and Fucoxanthin Ameliorate Cardiac Function of Aging Canine | Asian Journal of Animal and Veterinary Advances | |
| 2017 | Fucoidan Induces Toll-like Receptor 4-Regulated Reactive Oxygen Species and Promotes Endoplasmic Reticulum Stress-Mediated Apoptosis in Lung Cancer | Scientific Reports | |
| 2017 | Fucoidan Ameliorates Pancreatic β-Cell Death and Impaired Insulin Synthesis in Streptozotocin-Treated β cells and Mice via a Sirt-1-Dependent Manner | Molecular Nutrition & Food Research | |
| 2017 | Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial | Marine Drugs | |
| 2017 | Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes | Marine Drugs | |
| 2017 | Oligo-Fucoidan Prevents Renal Tubulointerstitial Fibrosis by Inhibiting the CD44 Signal Pathway | Scientific Reports | |
| 2016 | Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells | Journal of Cancer | |
| 2016 | A Mechanism of Low Molecular Weight Fucoidans Degraded by Enzymatic and Acidic Hydrolysis for the Prevention of UVB Damage | The Journal of Applied Phycology | |
| 2016 | Combined Administration of Fucoidan Ameliorates Tumor and Chemotherapy-Induced Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice | Oncotarget | |
| 2016 | The Oligo Fucoidan Inhibits Platelet-Derived Growth Factor-Stimulated Proliferation of Airway Smooth Muscle Cells | Marine Drugs | |
| 2016 | Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo | Marine Drugs | |
| 2016 | Low-Molecular-Weight Fucoidan and High-Stability Fucoxanthin from Brown Seaweed Exert Prebiotics and Anti-Inflammatory Activities in Caco-2 Cells | Food & Nutrition | |
| 2015 | The in vitro and in vivo effects of the low molecular weight Fucoidan on the bone osteogenic differentiation properties | Cytotechnology | |
| 2015 | Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia | Marine Drugs | |
| 2015 | Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells | Marine Drugs | |
| 2015 | Inhibitory effects of high stability fucoxanthin on palmitic acid-induced lipid accumulation in human adipose-derived stem cells through modulation of long non-coding RNA | Food & Function | |
| 2015 | The Brown Seaweed Sargassum hemiphyllum Exhibits a-Amylase and a-Glucosidase Inhibitory Activity and Enhances Insulin Release In Vitro | Cytotechnology | |
| 2015 | Inhibitory activity of Sargassum Hemiphyllum Sulfated Polysaccharide in Arachidonic Acid-Induced Animal Models of Inflammation | Journal of Food and Drug Analysis | |
| 2014 | Fucoxanthin-containing Ethanolic Extract from Sargassum hemiphyllum Inhibits Adipogenesis in 3T3-L1 Cells | Journal of Taiwan Fisheries Research | |
| 2014 | Fucoidan Inhibition of Lung Cancer in vivo and in vitro: Role of the Smurf2-Dependent Ubiquitin Proteasome Pathway in TGFβ Receptor Degradation | Oncotarget | |
| 2013 | Fucoidan Induces Changes in the Epithelial to Mesenchymal Transition and Decreases Metastasis by Enhancing Ubiquitin-Dependent TGFβ Receptor Degradation in Breast Cancer | CarcinoGenesis | |
| 2011 | Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Sargassum hemiphyllum Sulfated Polysaccharide Extract in RAW 264.7 Macrophage Cells | Journal of Agricultural and Food Chemistry | |
| 2010 | Antioxidant and Immune-Stimulating Activities of Hot-Water Extract from Seaweed Sargassum Hemiphyllum | Journal of Marine Science and Technology |